Protection against X-irradiation employing cysteamine derivatives in tissue culture and in mice
article
Series of aminoalkanethiols were investigated to determine their toxic behaviour and radioprotective activities at the cellular level in cultured human cells and in mice. The non-linear relationship between thiol concentration and survival of cells found in the concentration range of 0·2 to 8 mM under the present experimental conditions was also pH dependent. The toxicity of the thiols increased with an increase of pH from 6·3 to 8·3. However, the non-linear relationship between concentration and survival was not evident at pH 6·3. Increasing the pH of the cysteamine solution injected intraperitoneally in mice increased toxicity at the rate of 10·3 ± 4·6 mg/kg per pH unit.
TNO Identifier
357365
Source
International Journal of Radiation Biology, 18(2), pp. 111-126.
Pages
111-126
Files
To receive the publication files, please send an e-mail request to TNO Repository.