Dose-mortality studies for mice irradiated with X-rays, gamma-rays and 15 MeV neutrons
article
Acute mortality in mice, occurring within 5 or within 30 days after the end of the exposure, was studied after irradiation with x-rays, gamma-rays or 15 MeV neutrons in either 2-hour or 8-hour exposures. Death due to the haematopoietic syndrome occurred mainly between 8 and 14 days after exposure, whereas a mean survival time of 4-5 days was found for the intestinal syndrome. For 15 MeV neutron irradiations and 2-hour exposure time, the LD_50-values for the two syndromes differed by nearly 300 rads. Mortality due to the intestinal syndrome was not observed in the range of the lowest lethal doses. RBE-values of l•l and 1•4 with respect to 250 kVp x-rays were obtained for haematopoietic death and intestinal death, respectively. The effect of protraction of the exposures to gamma-rajrs and neutrons suggests that there are intrinsic differences between the ceUular radiosensitivity of intestinal cells and bone-marrow cells.
TNO Identifier
354525
Source
International Journal of Radiation Biology, 15(2), pp. 115-124.
Pages
115-124
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