Comparison of growth characteristics of experimental tumours and derived cell cultures
article
Cells from 7 different rat tumors and a mouse sarcoma have been transplanted in syngeneic animals and were cultured in vitro. Tumors produced by inoculation of cultured cells in animals have been compared with the primary tumors. For the transplanted tumors, volume doubling times, T(d), have been compared with doubling times T[d(cult)], of cell numbers in cultures. Volume doubling times of the transplanted tumors generally decrease with increasing volume. At volumes of about 0.5 cm3,T(d) values range from 2.2 days to 10 days, while T[d(cult)] valves ranged from 11 to 24 hr. A systematic correlation between T(d) and T[d(cult)] could not be established. During sequential transplantation of the tumors for many generations, as well as during continuous propagation of derived cell cultures, significant changes occurred which resulted in a decrease in the expression of differentiation characteristics in tumors.
Topics
cancer cell culturecancer graftcancer growthcell differentiationhistologyin vitro studymodelmouserattheoretical studyAnimalBone NeoplasmsCarcinomaCell DivisionCells, CulturedComparative StudyMiceNeoplasm TransplantationNeoplasms, ExperimentalRatsSarcoma, ExperimentalSkin NeoplasmsSupport, U.S. Gov't, P.H.S.Ureteral Neoplasms
TNO Identifier
228305
ISSN
00088730
Source
Cell and Tissue Kinetics, 10(5), pp. 469-475.
Pages
469-475
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