A new metastasizing mammary carcinoma model in mice: Model characteristics and applications
article
The criteria for a suitable experimental breast cancer model are discussed. Only one of a series of 9 tumor systems initially studied, consistently showed early lymph node and late lung metastases and fulfilled the criteria. This mammary carcinoma (2661) was more fully characterized and was found to be non-antigenic following s.c. and i.v. immunity challenge tests. Size of the primary tumor as well as lymph node palpation were shown to be crude indexes for survival. Metastases formation gave rise to changes in lymphatic drainage pathways. Combination adjuvant chemotherapy increased the survival time in treated animals and produced a striking difference in patterns of metastases distribution. Results on immunity, surgery and chemotherapy in regard to this model are discussed.
Chemicals/CAS: Antigens, Neoplasm
Chemicals/CAS: Antigens, Neoplasm
Topics
breast carcinomacancer chemotherapycancer graftcancer immunologycancer surgerylung metastasislymph node metastasismodelmousetheoretical studytherapyAnimalAntigens, NeoplasmDisease Models, AnimalDrug Therapy, CombinationFemaleLung NeoplasmsLymphatic MetastasisMammary Neoplasms, ExperimentalMiceNeoplasm Metastasis
TNO Identifier
228245
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 13(6), pp. 555-565.
Pages
555-565
Files
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