Cellular responses determining the effectiveness of fast neutrons relative to X-rays for effects on experimental tumours
article
Relations between the relative biological effectiveness of fast neutrons and the dose or daily dose fractions are presented for cultured cells, tumours and normal tissues. These relations are dependent on a variety of factors, namely the neutron energy spectrum, the shapes of dose-survival curves, repair of sub-lethal damage, the presence of anoxic cells, reoxygenation during intervals between fractions and the dependence of radiosensitivity on the age of cells in their cycle. The relative influence of these factors is discussed. Comparison of the RBE values of fast neutrons derived from published data for experimental tumours and normal tissues indicates that overall gain factors, RBE(tumour)/RBE(normal tissue), range between 1·1 and 1·3. A possible advantage of fast neutrons will depend on the type of tumour and the type of dose-limiting normal tissue. © 1971.
Chemicals/CAS: beryllium, 7440-41-7; carbon, 7440-44-0; helium, 7440-59-7; tritium, 10028-17-8; uranium, 7440-61-1; Beryllium, 7440-41-7; Carbon Isotopes; Helium, 7440-59-7; Radioisotopes; Tritium, 10028-17-8; Uranium, 7440-61-1
Chemicals/CAS: beryllium, 7440-41-7; carbon, 7440-44-0; helium, 7440-59-7; tritium, 10028-17-8; uranium, 7440-61-1; Beryllium, 7440-41-7; Carbon Isotopes; Helium, 7440-59-7; Radioisotopes; Tritium, 10028-17-8; Uranium, 7440-61-1
Topics
berylliumcarbonheliumradioisotopetritiumuraniumanimalanoxiacell survivalexperimental neoplasmhumankidneymegavoltage radiotherapymouseneutronosteosarcomaoxygen consumptionradiation doseradiation exposureradiation responseratreviewrhabdomyosarcomatissue cultureAnimalAnoxiaBerylliumCarbon IsotopesCell SurvivalHeliumHumanKidneyMiceNeoplasms, ExperimentalNeutronsOsteosarcomaOxygen ConsumptionRadiation EffectsRadioisotopesRadiotherapy DosageRadiotherapy, High-EnergyRatsRhabdomyosarcomaTissue CultureTritiumUranium
TNO Identifier
227254
ISSN
00142964
Source
European Journal of Cancer, 7(2-3), pp. 181-190.
Pages
181-190
Files
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