Effects of radiation on the reproductive capactity and proliferation of cells in relation to carcinogenesis
bookPart
The initiation and expression of malignant properties in cells, induced by exposure to ionizing radiation, is a multistep process that depends on a variety of factors. Some of the mechanisms involved in early stages of carcinogenesis can be studied in vitro for various types of cells. Analysis and interpretation of the dose-effect relations for carcinogenesis can benefit from studies on cellular effects, because quantitative assays are available for various end-points, including reproductive death, cell proliferative capacity, and cell transformation.
Some of the processes that constitute the sequence of events of tumor development,
and their modification by various agents and conditions, depend not only on responses of single cells, but also on interaction of cells in tissues and on the influence of host factors. The development of tumors may be influenced by immunologic and hormonal factors, as well as by an increese in the rate of cell proliferation caused by tissue damage or cell depletion. It is evident that the influence of these factors will depend on the type of tissue involved. This chapter discusses only some general features of the induction of various types of damage in cultured cells, and their consequences for tumor development.
Some of the processes that constitute the sequence of events of tumor development,
and their modification by various agents and conditions, depend not only on responses of single cells, but also on interaction of cells in tissues and on the influence of host factors. The development of tumors may be influenced by immunologic and hormonal factors, as well as by an increese in the rate of cell proliferation caused by tissue damage or cell depletion. It is evident that the influence of these factors will depend on the type of tissue involved. This chapter discusses only some general features of the induction of various types of damage in cultured cells, and their consequences for tumor development.
TNO Identifier
356150
ISBN
0-444-00859-4
Publisher
Elsevier
Source title
Radiation carcinogenesis
Editor(s)
Upton, A.C.
Albert, R.E.
Burns, F.J.
Shore, R.E.
Albert, R.E.
Burns, F.J.
Shore, R.E.
Place of publication
New York etc.
Pages
85-105
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