Differences in radiosensitivity among cells in culture and in experimental tumours: Significance for the effectiveness of human cancer therapy
article
Problems in the application of radiobiological data on various types of models, cell in vitro, experimental tumours, and clinical models, to the prediction of tumour radiocurability are discussed. On the basis of observations on cells in culture and experimental tumours it is suggested that heterogeneity in responsiveness of tumours in patients is caused in a large part by differences in intrinsic cellular radiosensitivity. Methods and developments are reviewed, which may yield better assays for the prediction of tumour responsiveness to treatments.
Topics
TNO Identifier
230370
ISSN
01678140
Source
Radiotherapy and Oncology, 8(4), pp. 285-300.
Pages
285-300
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