The DR system of rhesus monkeys : A brief review of serology, genetics, and relevance to transplantation
article
The DR locus of rhesus monkeys and the relevance of its products to histocompatibility was briefly reviewed. Current knowledge of serology and genetics reveal that, as in man, the DR locus of the rhesus monkey is less polymorphic than the A or B loci of the MHC, that DR antigens are highly associated (or identical) with the D or major MLC locus antigens and that there are several groups of cross-reacting DR antigens. Further, there is evidence for the existence of (B-cell-specific) Ia antigens that are not controlled by DR but by other genes, located inside or outside the RhLA region. With regard to histocompatibility, matching unrelated individuals for DR antigens (and, by implictions, for D antigens) has a highly beneficial influence on kidney allograft prognosis. However, provisional data indicate that DR matching of unrelated monkeys does not have a beneficial influence on skin graft survival or on the fate of lethally irradiated monkeys treated with hemopoietic stem cell concentrates. Matching for SD antigens, on the other hand, does not improve kidney allograft prognosis, but has a distinctly positive influence on skin and bone marrow transplanation among unrelated rhesus monkeys.
Chemicals/CAS: Histocompatibility Antigens Class II; Histocompatibility Antigens
Chemicals/CAS: Histocompatibility Antigens Class II; Histocompatibility Antigens
Topics
b lymphocyteblood and hemopoietic systemblood group rhesus systemheredityin vitro studylymphatic systemlymphocyte culturemajor histocompatibility complexmonkeyreviewtransplantationAnimalBlood TransfusionBone Marrow TransplantationChromosome MappingHistocompatibility AntigensHistocompatibility Antigens Class IIHumanKidney TransplantationLymphocyte Culture Test, MixedMacaca mulattaModels, BiologicalSkin TransplantationSupport, Non-U.S. Gov'tTransplantation, Homologous
TNO Identifier
228943
ISSN
00411345
Source
Transplantation Proceedings, 12(3), pp. 502-508.
Pages
502-508
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