The major histocompatibility complex of rhesus monkeys. XII: Cellular typing for D locus antigens in families
article
Typing cells (TC) were used for the identification of D locus antigens in rhesus monkey families. The antigens defined by this cellular method always segregated with the other RhLA-controlled markers except in one offspring with a proven recombination within the RhLA region; in that case, the D antigen was inherited in coupling with an antigen of the Ia1 locus (the analog of the human DR locus). With two exceptions, each TC or group of TCs was associated with one of the serologically defined Ia1 antigens. The two exceptions were associated with 'blanks' of that series. Interestingly, two independent (mutually MLC responsive) TC groups appeared to be associated with the same Ia1 antigens 75. Equally noteworthy was the observed 'inclusion phenomenon' among cells of several TC groups, each associated with a single Ia1 antigen or blank of that series. In these cases, some of the TCs of the group were unidirectionally MLC-responsive against other cells of the same group. Certain pitfalls of cellular typing are discussed; unexcpected 'false positive' results were attributed to prior immunization with products of non-D loci which have been described recently.
Chemicals/CAS: Epitopes; Isoantibodies; Isoantigens
Chemicals/CAS: Epitopes; Isoantibodies; Isoantigens
Topics
gene segregationheredityin vitro studymajor histocompatibility complexmixed lymphocyte reactionmonkeytissue typingAnimalChromosome MappingEpitopesFemaleGenotypeHaplorhiniHistocompatibility TestingImmunizationIsoantibodiesIsoantigensLymphocyte Culture Test, MixedMacacaMacaca mulattaMajor Histocompatibility ComplexMaleRecombination, Genetic
TNO Identifier
228744
ISSN
0001-2815
Source
Tissue Antigens, 13(4), pp. 255-272.
Pages
255-272
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