Homogeneous antibodies in lethally irradiated and autologous bone marrow reconstituted Rhesus monkeys
article
10 rhesus monkeys were lethally irradiated and reconstituted with autologous bone marrow. During the restoration period, the animals were immunized with DNP Rhesus albumin and IgA1λ 10S human paraprotein. One or more transient homogeneous immunoglobulin components appeared in sera of all monkeys. In 4 animals, these homogeneous immunoglobulins were shown to be specific antibodies against DNP Rhesus albumin. They gradually became as heterogeneous as those in control monkeys which were immunized but not irradiated and transplanted. The onset of the specific antibody response after immunization was slightly delayed in the experimental group. On determining the time necessary to reach normalization of the overall immunoglobulin levels and the normal heterogeneity of the immunoglobulin spectrum, it was found to be more than 1 yr in most of the animals.
Topics
TNO Identifier
228119
ISSN
00099104
Source
Clinical and Experimental Immunology, 23(2), pp. 355-359.
Pages
355-359
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