Fibrinolytic activators and inhibitors in terminal renal insufficiency and in anephric patients
article
Fibrinolytic factors were measured before and after DDAVP-infusion in 18 patients on chronic, regular haemodialysis, 11 of whom underwent bilateral nephrectomy, and in 7 patients in whom non-functioning kidneys were still present. Baseline fibrinolytic activity was normal or high in all but two cases. Before haemodialysis, the response to DDAVP-infusion was greatly reduced in the majority of patients as compared with healthy controls, irrespective of the baseline level. This was in accordance with mean t-PA-antigen levels which increased only slightly after DDAVP. When DDAVP was given after haemodialysis, previous non-responders showed a normal increase in fibrinolytic activity. The level of free t-PA-inhibitors was normal in most cases as were levels of ??2-antiplasmin and ??2-macroglobulin. Chemicals/CAS: desmopressin, 16679-58-6; plasminogen activator, 9039-53-6; alpha-Macroglobulins; Antigens; Antiplasmin; Desmopressin, 16679-58-6; Factor VIII, 9001-27-8; Plasminogen Activators, EC 3.4.21.-; von Willebrand Factor
Topics
desmopressinplasminogen activatorblood and hemopoietic systemclinical articlehemodialysishumanhuman cellkidneykidney failurenephrectomypriority journalalpha-MacroglobulinsAntigensAntiplasminComparative StudyDesmopressinFactor VIIIFibrinolysisHumanKidney Failure, ChronicNephrectomyPlasminogen ActivatorsRenal DialysisSupport, Non-U.S. Gov'tvon Willebrand Factor
TNO Identifier
229684
ISSN
03406245
Source
Thrombosis and Haemostasis, 52(3), pp. 311-314.
Pages
311-314
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