Ageing of the lymphoid system at the organ level. With special reference to the bone marrow as site of antibody production
article
The capacity of an organism to mediate an effective immune response towards antigens challenging that organism for the first time declines during aging. This has been shown for both cell mediated and humoral immune responses, on the other hand, the overall immunological activity, as judged from the serum immunoglobulin levels and the total number of cytoplasmic immunoglobulin positive cells (C-Ig cells), does not decrease during ageing. The latter was found to be independent of the presence of the thymus. The distribution of the C-Ig cells over various lymphoid organs, however, changes considerably during life. C-IgM as well as C-IgG and C-IgA cells accumulate in the bone marrow with increasing age, suggesting an increasing antibody production within the bone marrow during ageing. This paper pays special attention to the bone marrow as site of antibody production.
Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin M, 9007-85-6
Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin M, 9007-85-6
Topics
TNO Identifier
228417
ISSN
03781186
Source
Nederlands Tijdschrift voor Gerontologie, 9(4), pp. 225-230.
Pages
225-230
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