An improved synthesis of the antithyroid factor DL-goitrin

article



Brandsma, L.

Bos, K.D.

Keegstra, M.A.

Verkruysse, H.D.
DL-1-Amino-3-buten-2-ol HH2CCH-CH(OH)-CH2NH2 has been synthesized in a satisfactory overall yield by reduction of the protected cyanohydrin H2CCH-CH(OR)-CN [R = -CH(CH3)OC2H5] with aluminum hydride, followed by removal of the protecting group with aqueous hydrochloric acid and treatment with potassium hydroxide. The amino alcohol is a key intermediate in a synthesis of the antithyroid factor goitrin reported previously.
Topics


MedicineGeneeskundePathology
TNO Identifier
62819
Repository link
https://resolver.tno.nl/uuid:01ae5757-c627-4533-a63d-aa49543e1bda
Source
Recueil des Travaux Chimiques des Pays-Bas, 107(3), pp. 132-133.
Pages
132-133
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