Surface immunoglobulins in chronic lymphatic leukaemia, macroglobulinaemia and myelomatosis
article
The direct method of immunofluorescence was applied for the detection of surface immunoglobulins (Ig) on lymphocytes, obtained from bone marrow and peripheral blood, especially from patients with paraproteinemia. The results in chronic lymphatic leukemia (CLL), in the macroglobulinemia of Waldenstrom (MW), and in multiple myeloma (MM) show three different patterns as far as the relationship between cytoplasmic and membrane Ig is concerned. In CLL a monoclonal proliferation of cells with surface Ig was found, but the percentage of cells with cytoplasmic fluorescence was normal. In MW the further differentiation in Ig secreting cells seems to be intact. In MM the percentage of lymphocytes in the peripheral blood with membrane bound Ig was within normal limits or decreased. These data suggest that MM can be considered as a neoplasia of already differentiated Ig secreting cells, localized in the bone marrow. The combined information again indicates the central role of human bone marrow for antibody production. Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin, 9007-83-4; immunoglobulin M, 9007-85-6; Binding Sites, Antibody; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins, kappa-Chain; Immunoglobulins, lambda-Chain; Immunoglobulins, Surface
Topics
immunoglobulinimmunoglobulin gparaproteinimmunoglobulin Aimmunoglobulin Gimmunoglobulin kappa chainimmunoglobulin lambda chainimmunoglobulin MImmunoglobulins, kappa ChainImmunoglobulins, lambda Chainlymphocyte membrane immunoglobulinbone marrowcell membranechronic lymphatic leukemiain vitro studyinternal medicinelymphocytemacroglobulinemiamajor clinical studymultiple myelomatheoretical studywaldenstroem macroglobulinemiaadolescentadultantibody combining sitebone marrow cellchildfetus bloodfluorescent antibody techniquehumanimmunologyinfantlymphatic leukemiapreschool childWaldenstroem macroglobulinemiafluorescence microscopynewbornAdolescentAdultBinding Sites, AntibodyBone MarrowBone Marrow CellsChildChild, PreschoolFetal BloodFluorescent Antibody TechniqueHumanImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunoglobulins, kappa-ChainImmunoglobulins, lambda-ChainImmunoglobulins, SurfaceInfantLeukemia, LymphocyticLymphocytesMiddle AgeMultiple MyelomaWaldenstrom MacroglobulinemiaInfant, NewbornMicroscopy, Fluorescence
TNO Identifier
227746
ISSN
00099104
Source
Clinical and Experimental Immunology, 16(4), pp. 541-552.
Pages
541-552
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