In vivo models for testing of cytostatic agents in non-small cell lung cancer
bookPart
The limited progress in non-small cell lung cancer (NSCLC) in numerous clinical trials is rather disappointing. There is a need for more detailed information on the specific biological properties of the various forms of lung cancer before a more rational approach in the improvement of treatment can be made. In contrast to the situation in other forms of cancer, e.g., lymphoid and myeloid leukemia, mammary cancer, and colon cancer, there has been a noticeable scarcity of useful animal models for the study of the biological properties of lung tumors and their responsiveness to chemo-therapeutics and radiation. In general, a particular tumor model should be chosen based upon the specific question to be answered. One of the major areas of research is response to treatment. Human lung tumor xenografts have been used as tools to study responsiveness to treatment modalities, and rodent lung tumor models were developed that can be used for this purpose. In this chapter, the xenograft model and the rodent lung tumor models will be described with respect to their responsiveness to cytostatic agents.
Topics
TNO Identifier
232912
ISSN
0927-3042
Source
Lung Cancer. Cancer Treatment and Research, 72, pp. 155-169.
Publisher
Springer
Editor(s)
Hansen, H.H.
Place of publication
Boston
Pages
155-169
Files
To receive the publication files, please send an e-mail request to TNO Repository.