Transthyretin (prealbumin) binding of PCBS, a model for the mechanism of interference with vitamin A and thyroid hormone metabolism

article



Brouwer, A.

Berg, K.J. van den

Blaner, W.S.

Goodman, D.S.
In this study a direct interaction of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl with transthyretin (prealbumin) was observed, leading to reduced plasma levels of retinol, RBP and thyroxin in rats and mice. Chemicals/CAS: 3,3',4,4' tetrachlorobiphenyl, 32598-13-3; retinol, 68-26-8, 82445-97-4
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3,3',4,4' tetrachlorobiphenylprealbuminretinolanimal experimentbiological modelintoxicationmetabolitemodelmousenonhumanprotein bindingratthyroxine blood level
TNO Identifier
230246
Repository link
https://resolver.tno.nl/uuid:aa16bc43-6285-4fd9-b7d1-6fae005b8419
ISSN
00456535
Source
Chemosphere, 15(9-12), pp. 1699-1706.
Pages
1699-1706
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