Cell transformation in vitro by fast neutrons of different energies: Implications for mechanisms
article
Studies have been performed to analyse the dependence of the induction of cell transformation and cell reproductive death in cultures of C3H/10T 1/2 cells, NBCH-3 cells and WAGR-2 cells on the energy of monoenergetic fast neutrons. The dose-effect relations for 300 kV X rays, 15 MeV, 4.2 MeV and 0.5 MeV neutrons have been analysed on the basis of the representations F(D) = t1D+t2D2 and S(D)/S(O) = exp [-(a1D + a2D2)] for transformation and survival respectively. The results show that a1 values for all radiations are a factor of approximately 103 larger than corresponding t1 values. The RBE values for cell reproductive death derived as ratios of a1 for the various neutrons and 300 kV X rays are similar to the corresponding RBE values for cell transformation derived as ratios of t1 values of neutrons and X rays. These similarities in the RBE values and differences in absolute values of a1 and t1 can be compared with results form published dose-effect relations for reproductive death and chromosome aberrations obtained for other cell lines. The insights obtained can be applied to derive a hypothesis about the induction of these effects, assuming similarities in energy requirements and physico-chemical primary mechanisms of the induction of damage in chromosomes and differences in the specificities of the sites and total size of the targets on chromosomes associated with the various endpoints observed.
Topics
TNO Identifier
229931
ISSN
01448420
Source
Radiation Protection Dosimetry, 13(1-4), pp. 145-148.
Pages
145-148
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