Radiation tolerance of the rat spinal cord: time dose relationships
article
The cervical or lumbosacral region of the rat spinal cord was irradiated with 300 kV x rays. Syndromes of radiation myelopathy similar to those in man were observed in the rats. Iso effect curves for tolerance in relation to the number of fractions at daily intervals have a slope of 0.44 and 0.42 on a log log scale for the cervical and lumbosacral regions, resp. With intervals of up to 7 days, no significant further increase in tolerance was observed. Low dose rate treatments indicate a half time of 1.5 hr. for repair of subeffective damage. These results suggest that tolerance of the spinal cord depends very strongly on the number of fractions given and only to a small extent on the overall time of treatment.
Topics
histologymethodologyradiation dose fractionationradiation injuryradiosensitivityratspinal cordtheoretical studyX rayAnimalComparative StudyDose-Response Relationship, RadiationLumbosacral RegionMaleMotor ActivityMuscular AtrophyNeckParalysisRadiation DosageRadiation ToleranceRatsSpinal CordSpinal Cord DiseasesTime Factors
TNO Identifier
228163
ISSN
00338419
Source
Radiology, 122(2), pp. 505-509.
Pages
505-509
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