Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?
article
The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthritogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.
Topics
TNO Identifier
231027
ISSN
01728172
Source
Rheumatology International, 10(1), pp. 21-29.
Pages
21-29
Files
To receive the publication files, please send an e-mail request to TNO Repository.