Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease
article
Several studies have reported an association of the apolipoprotein E allele ε4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. Chemicals/CAS: apolipoprotein E-4; Apolipoproteins E
Topics
TNO Identifier
280587
ISSN
10614036
Source
Nature Genetics, 7(1), pp. 74-78.
Pages
74-78
Files
To receive the publication files, please send an e-mail request to TNO Repository.