Characterization of a subpopulation in neonatal thymus which suppresses the graft-vs.-host reaction
article
Thymus cells from neonatal and infant mice were found to have a high capacity to prevent mortality from acute graft-vs-host disease as compared with spleen cells from stable radiation chimeras. This suppressive capacity of thymocytes decreases with age after birth as was demonstrated by semi-quantitative cell titrations. This suppressor activity is restricted to syngeneity of the graft-vs.-host disease-including cells. The thymic suppressor cells are Thy-1+ and Lyt-1+ and IgG- and IgM-. They do not agglutinate with peanut agglutinin and have a high electrophoretic mobility. In vitro irradiation experiments showed that the suppressor cells are radiation sensitive. These results are compared with the available information on cells suppressing delayed-type hypersensitivity reactions and those suppressing B cell responses.
Topics
animal experimentdelayed hypersensitivitymousenewbornnonhumansuppressor cellthymusAnimalAnimals, NewbornAntigens, SurfaceArachis hypogaeaFlow CytometryGraft vs Host ReactionLectinsLymphocytesMiceMice, Inbred StrainsPeanut AgglutininPhenotypeSupport, Non-U.S. Gov'tT-Lymphocytes, Suppressor-EffectorThymus Gland
TNO Identifier
229375
ISSN
00142980
Source
European Journal of Immunology, 13(5), pp. 403-409.
Pages
403-409
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