Effect of succinylated Acinetobacter glutamine-asparaginase treatment on an acute myeloid leukemia in the rat (BNML)
article
The effect of succinylated Acinetobacter glutaminase-asparaginase (G-A) treatment was investigated in the Brown Norway myeloid rat leukemia (BNML). It was observed that a daily treatment schedule of 400 i.u./kg for 7 days was effective when liver and spleen weight were used as criteria. However, no effect was seen in the bone marrow, which indicates that either pharmocokinetic distribution parameters or differences in sensitivity may influence the outcome of this treatment. Since similar results were observed in children with acute lymphocytic leukemia, the BNML offers a good experimental model to study the effects of G-A treatment on leukemic cells.
Topics
asparaginaseglutaminaseacinetobacteracute myeloblastic leukemiaanimal experimentblood and hemopoietic systemcancer chemotherapyglutaminase asparaginaseleukemia celllymphatic systemmyeloid leukemiaratAcinetobacterAnimalAsparaginaseDisease Models, AnimalGlutaminaseLeukemia, ExperimentalLeukemia, Myelocytic, AcuteNeoplasm TransplantationRatsRats, Inbred BNTransplantation, Homologous
TNO Identifier
228762
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 15(8), pp. 1061-1063.
Pages
1061-1063
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