Protection against X-irradiation by some orally administered compounds
article
A number of compounds were studied that protected mice against LD(50/30) after X-irradiation. For three compounds (WR 109342, WR 158490 and WR 159243) dose reduction factors between 1.7 and 1.8 were obtained after oral administration. Blood taken from mice that had been treated with these protective compounds provided virtually no protection of HeLa cells in vitro, whereas when blood from cysteamine treated mice was tested in vitro, protection could be demonstrated. This may indicate different mechanisms of action.
Chemicals/CAS: Adamantane, 281-23-2; Amidines; Radiation-Protective Agents; Thiazoles; WR 109342, 58319-26-9
Chemicals/CAS: Adamantane, 281-23-2; Amidines; Radiation-Protective Agents; Thiazoles; WR 109342, 58319-26-9
Topics
5 chloro 2 (3 thiazolidinylheptylthio)pyridineAnimal experimentBis(acetamidino) disulfideDose responseDrug mechanismDrug responseDrug screeningFemale genital systemHela cellHumanHuman cellIn vitro studyInjuryMethanethiol derivativeMouseN (1 adamantylmethyl)thioglycolamidineOral drug administrationRadiation protectionThiomesylic acid derivativeAdamantaneAdministration, OralAmidinesAnimalComparative StudyMaleMiceRadiation-Protective AgentsThiazoles
TNO Identifier
229605
ISSN
09553002
Source
International Journal of Radiation Biology, 45(5), pp. 479-486.
Pages
479-486
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