The Rhesus monkey as a preclinical model for bone marrow transplantation
article
The rhesus monkey provides a near optimal model for preclinical investigations of bone marrow transplantation in that its radiosensitivity, the composition of its bone marrow, and its immunobiologic reactions to bone marrow grafting are closely similar to those of humans. Modifications of the acute GVHD, which develops after grafting of marrow from unrelated nonmatched donors, have proved to be highly predictive for the human situation. Future advances in results and feasibility of bone marrow transplantation between non-siblings are clearly dependent on progress in matching by means of tissue typing. The methodology and knowledge of tissue typing in rhesus monkeys is presently comparable to that in man.
Topics
animal experimentbiological modelbone marrow transplantationgraft versus host reactionmonkeytheoretical studytissue typingAnimalAntilymphocyte SerumBone Marrow CellsBone Marrow TransplantationCyclophosphamideGraft vs Host DiseaseHaplorhiniInjections, IntraperitonealInjections, IntravenousLiver TransplantationMacacaMacaca mulattaModels, BiologicalRadiation DosageTransplantation, Homologous
TNO Identifier
228348
ISSN
00411345
Source
Transplantation Proceedings, 10(1), pp. 105-111.
Pages
105-111
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