Short-term effects of marginal vitamin B deficiencies on immune parameters in healthy young volunteers
article
Twenty-four healthy, male volunteers (age 20-30 years) participated in a 14-week double blind study to determine the influence of marginal vitamin B-1, B-2 and/or B-6 deficiency on humoral (IgG, IgA, IGM, IgE, IgD) and cellular (total lymphocyte count, OKT3/Cd3, OKT4/Cd4, OKT8/Cd8, OKT9/Cd71, OKT10/Cd38, OKT11/Cd2, Leu1/Cd5, Leu7/Cd57, Leu11/Cd16, IL-2 receptor/Cd25, BA1/Cd24, B4/Cd19 and OKIa/HLA-Dr positive lymphocytes) immunity as well as on acute-phase reactants (C3, C4, C3 pro-activator and α-1-acid glycoprotein, α-1-antitrypsin, haptoglobin, ceruloplasmin, transferrin, prealbumin and C-reactive protein). The diet consisted of conventional, mixed solid foods, deficient in vitamin B-1 (0.43 mg/d), B-2 (0.94 mg/d) and B-6 (0.39 mg/d). The volunteers were either or not supplemented with one or more of the vitamins B-1, B-2 and B-6, thus constituting 8 experimental groups. Although at the end of 11 weeks of depletion statistically significant differences (p < 0.05 or p < 0.025) between the deficient and non-deficient groups were found for some immune status parameters, we concluded that these differences do not imply physiologically important effects.
Topics
TNO Identifier
231180
DOI
https://dx.doi.org/10.1016/S0271-5317(05)80058-2
ISSN
02715317
Source
Nutrition Research, 10(5), pp. 483-492.
Pages
483-492
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