Short-term effects of marginal vitamin B deficiencies on immune parameters in healthy young volunteers
article
Twenty-four healthy, male volunteers (age 20-30 years) participated in a 14-week double blind study to determine the influence of marginal vitamin B-1, B-2 and/or B-6 deficiency on humoral (IgG, IgA, IGM, IgE, IgD) and cellular (total lymphocyte count, OKT3/Cd3, OKT4/Cd4, OKT8/Cd8, OKT9/Cd71, OKT10/Cd38, OKT11/Cd2, Leu1/Cd5, Leu7/Cd57, Leu11/Cd16, IL-2 receptor/Cd25, BA1/Cd24, B4/Cd19 and OKIa/HLA-Dr positive lymphocytes) immunity as well as on acute-phase reactants (C3, C4, C3 pro-activator and α-1-acid glycoprotein, α-1-antitrypsin, haptoglobin, ceruloplasmin, transferrin, prealbumin and C-reactive protein). The diet consisted of conventional, mixed solid foods, deficient in vitamin B-1 (0.43 mg/d), B-2 (0.94 mg/d) and B-6 (0.39 mg/d). The volunteers were either or not supplemented with one or more of the vitamins B-1, B-2 and B-6, thus constituting 8 experimental groups. Although at the end of 11 weeks of depletion statistically significant differences (p < 0.05 or p < 0.025) between the deficient and non-deficient groups were found for some immune status parameters, we concluded that these differences do not imply physiologically important effects.
Topics
TNO Identifier
231180
ISSN
02715317
Source
Nutrition Research, 10(5), pp. 483-492.
Pages
483-492
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