Effects of cyclosporin A on experimental graft-versus-host disease in rodents
article
Cyclosporin A was tested in several mouse and rat models for its mitigating influence on GVHD. It was effective in rats and mice following s.c. administration in suppressing acute and delayed GVHD. Oral administration of CY-A in mice proved ineffective and was accompanied by severe toxicity; specific lesions were observed in the kidney, the liver, and the lung. Our results suggest a myelosuppressive effect of the higher doses of CY-A in animals given bone marrow grafts, which necessitates more refined identification of the tolerable and effective dose range in various animal species.
Topics
cyclosporin aanimal experimentautopsydrug efficacygraft versus host reactionhistologyimmunosuppressive treatmentoral drug administrationratsubcutaneous drug administrationAdministration, OralAnimalBone Marrow TransplantationComparative StudyCyclosporinsGraft vs Host ReactionImmunosuppressive AgentsInjections, SubcutaneousKidneyLiverLungMicePeptides, CyclicRatsSpecies Specificity
TNO Identifier
228891
ISSN
00411345
Source
Transplantation Proceedings, 12(2), pp. 278-282.
Pages
278-282
Files
To receive the publication files, please send an e-mail request to TNO Repository.