Response to activated protein C in subjects with and without dementia
article
We performed a cross-sectional case-control study among 295 subjects with dementia and 406 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, to evaluate the association of the factor V Leiden mutation and activated protein C (APC) response with dementia and its subtypes. The risk of dementia was 2.11-fold increased among carriers of factor V Leiden mutation relative to subjects lacking factor V Leiden mutation (95% confidence interval, Cl, 0.93-4.77). The increased risks of vascular dementia and of Alzheimer's disease were 4.28 (95% Cl 1.2G-14.5) and 2.15 (95% Cl 0.82-5.63), respectively. No association was found for ARC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia. © 1999 S. Karger AG.
Topics
Historisch materiaal TNOActivated protein C resistanceArterial diseaseCoagulationFactor V LeidenFactor V mutationPopulationThrombosisActivated Protein C ResistanceAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCohort StudiesCross-Sectional StudiesDementiaDementia, VascularFactor VFemaleHumansMaleMiddle AgedNetherlandsPoint MutationProspective StudiesRisk Factors
TNO Identifier
234715
ISSN
03010147
Source
Haemostasis, 28(3-4), pp. 209-215.
Pages
209-215
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