The inability of propranolol and aspirin to inhibit the response of fibrinolytic activity and factor VIII-antigen to infusion of DDAVP
article
We tested the response of the fibrinolytic activity and factor VIII-antigen levels to infusion of DDAVP in healthy volunteers and we studied the influence of propranolol and aspirin on this response. After DDAVP, 0.4 ??g/kg in 10 min i.v., the fibrinolytic activity of redissolved euglobulins rose from 179 to 452 mm2 (lysis area of fibrin plates); after pretreatment with propranol, 320 mg per day during 7 days, DDAVP induced a similar rise (from 166 to 471 mm2) and after pretreatment with a single dose of aspirin, 600 mg, ingested 5 hr before the DDAVP infusion, the lysis area increased from 159 to 455 mm2. Factor VIII-antigen level increased within 60 min after DDAVP from 104 to 208%; after pretreatment with propranolol from 111 to 230% and after a single dose of aspirin, DDAVP induced a rise from 107 to 206%. From these data we conclude that neither baseline levels nor the release of plasminogen activator or factor VIII after DDAVP infusion are influenced by ??-blockade or by interference with prostaglandin synthesis.
Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; blood clotting factor 8, 9001-27-8; desmopressin, 16679-58-6; plasminogen activator, 9039-53-6; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Antigens; Argipressin, 113-79-1; Aspirin, 50-78-2; Desmopressin, 16679-58-6; Factor VIII, 9001-27-8; Propranolol, 525-66-6; von Willebrand Factor
Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; blood clotting factor 8, 9001-27-8; desmopressin, 16679-58-6; plasminogen activator, 9039-53-6; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Antigens; Argipressin, 113-79-1; Aspirin, 50-78-2; Desmopressin, 16679-58-6; Factor VIII, 9001-27-8; Propranolol, 525-66-6; von Willebrand Factor
Topics
acetylsalicylic acidblood clotting factor 8desmopressinplaceboplasminogen activatorpropranololprostaglandinblood and hemopoietic systemclinical trialcontrolled studydrug antagonismdrug comparisondrug mixturefibrinolysishumanintravenous drug administrationnormal humanvolunteerAntigensArgipressinAspirinBlood PressureDesmopressinFactor VIIIFibrinolysisFlushingHeart RateHumanMalePropranololSupport, Non-U.S. Gov'tvon Willebrand Factor
TNO Identifier
229543
ISSN
03406245
Source
Thrombosis and Haemostasis, 51(1), pp. 42-44.
Pages
42-44
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