Immunoglobulins and transient paraproteins in sera of patients with the Wiskott Aldrich syndrome: a follow up study

article


Radl, J.

Dooren, L.J.

Morell, A.
Immunoglobulin levels of individual classes and IgG subclasses and the occurrrence of homogeneous immunoglobulins, paraproteins, were studied longitudinally in the sera of three patients with the Wiskott Aldrich syndrome. Common findings in all 3 patients were great variations in the immunoglobulin levels, restricted heterogeneity of the immunoglobulins, the frequent appearance of transient homogeneous immunoglobulins and the presence of serum antibodies against bovine milk proteins. A partial and selective deficiency involving mainly the T immune system is postulated as an explanation for these findings.
Chemicals/CAS: protein, 67254-75-5; Antibodies; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; Milk Proteins; Paraproteins
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proteinchildimmune deficiencyimmunoglobulin blood levelin vitro studymajor clinical studytheoretical studywiskott aldrich syndromeAntibodiesHumanImmunoglobulin DImmunoglobulin GImmunoglobulin MInfantMaleMilk ProteinsParaproteinsTime FactorsWiskott-Aldrich Syndrome
TNO Identifier
228134
Repository link
https://resolver.tno.nl/uuid:fd7aaeb0-6b7e-4fac-beeb-96f705a52b06
ISSN
00099104
Source
Clinical and Experimental Immunology, 25(2), pp. 256-263.
Pages
256-263
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