Sensitive markers of inflammation make it possible to study the chronic process: The rise of interest in low levels of C-reactive protein

article

Kluft, C.

Maat, M.P.M.de
Increases in baseline levels of C-reactive protein (CRP) have been consistently identified as an independent risk indicator of cardiovascular events. The measurement of the low level is robust and well established. Increases in low levels of CRP can mark low-grade continuous inflammation and hyperresponse in acute situations. In addition, CRP can exert various actions on vascular cells and activates complement thus participating in infarction pathogenesis. Various cardiovascular drugs, notably statins, can induce a marked decrease in low levels of CRP, which is indicative of their beneficial effect on inflammation. Future studies need to demonstrate whether increases in baseline levels of CRP can become a useful practical addition to risk recognition strategies and possibly may also serve as an additional surrogate end-point in cardiovascular disease treatments. © 2002 Elsevier Science Inc. All rights reserved.
Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; alcohol, 64-17-5; atorvastatin, 134523-00-5, 134523-03-8; C reactive protein, 9007-41-4; cholesterol, 57-88-5; complement, 9007-36-7; fibrinogen, 9001-32-5; fluindostatin, 93957-54-1; intercellular adhesion molecule 1, 126547-89-5; mevinolin, 75330-75-5; phospholipase A2, 9001-84-7; pravastatin, 81131-74-0; simvastatin, 79902-63-9; troglitazone, 97322-87-7; Biological Markers; C-Reactive Protein, 9007-41-4
Topics





AnimalsBiological MarkersC-Reactive ProteinChronic DiseaseHumansInflammation
TNO Identifier
236622
Repository link
https://resolver.tno.nl/uuid:51b80a3b-e891-4717-97e2-d31d586a60c5
ISSN
15371891
Source
Vascular Pharmacology, 39(3), pp. 99-104.
Pages
99-104
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