Local tissue factor pathway inhibitor release in the human forearm
article
Nineteen healthy men received unilateral brachial artery infusions of either unfractioned heparin (0.3-100 IU/min), saline or the endothelium-dependent vasodilators substance P (2-8 pmol/min) and bradykinin (100-1000 pmol/min), and the endothelium-independent vasodilator sodium nitroprusside (2-8 μg/min). Heparin caused a dose-dependent increase in plasma TFPI concentrations in both arms (ANOVA, p <0.0001). Estimated net forearm TFPI release was 7 ± 16, 29 ± 20 and 138 ± 72 ng/100 mL tissue/min during 10, 30 and 100 IU/min of heparin respectively (ANOVA, p <0.0001). Compared to the systemic circulation, the forearm sensitivity to heparin induced TFPI release was 3.6-fold lower (166 ± 67 ng/IU vs. 596 ± 252 ng/IU: t-test, p = 0.004). Substance P, bradykinin and sodium nitroprusside all caused substantial dose-dependent increases in blood flow (ANOVA, p <0.001 for all) without affecting plasma TFPI concentrations. There are important regional differences in endothelial TFPI release, with the forearm circulation being relatively insensitive to heparin.
Chemicals/CAS: bradykinin, 58-82-2, 5979-11-3; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; nitroprusside sodium, 14402-89-2, 15078-28-1; prothrombin, 9001-26-7; sodium chloride, 7647-14-5; substance P, 33507-63-0; tissue factor pathway inhibitor, 116638-34-7; tissue plasminogen activator, 105913-11-9; Bradykinin, 58-82-2; Heparin, 9005-49-6; lipoprotein-associated coagulation inhibitor; Lipoproteins; Nitroprusside, 15078-28-1; Substance P, 33507-63-0; Vasodilator Agents
Chemicals/CAS: bradykinin, 58-82-2, 5979-11-3; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; nitroprusside sodium, 14402-89-2, 15078-28-1; prothrombin, 9001-26-7; sodium chloride, 7647-14-5; substance P, 33507-63-0; tissue factor pathway inhibitor, 116638-34-7; tissue plasminogen activator, 105913-11-9; Bradykinin, 58-82-2; Heparin, 9005-49-6; lipoprotein-associated coagulation inhibitor; Lipoproteins; Nitroprusside, 15078-28-1; Substance P, 33507-63-0; Vasodilator Agents
Topics
TNO Identifier
236982
ISSN
03406245
Source
Thrombosis and Haemostasis, 89(3), pp. 438-445.
Pages
438-445
Files
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