Quantifying Interactions between Physiological Signals to Identify Exposure to Different Chemicals
conference paper
Early detection of exposure to a toxic can be life-saving. We previously found that continuously recorded physiology in guinea pigs can be used for early detection of exposure to an opioid (fentanyl) or a nerve agent (VX), as well as for differentiating between the two. Here, we investigate how exposure to different chemicals affect the relation between ECG and respiration parameters as determined by Granger causality. Features reflecting such interactions may provide additional information and improve models differentiating between chemical agents. We found that all examined ECG and respiration parameters are Granger-related under healthy conditions, and that exposure to fentanyl and VX led to changes in these relations. Importantly, we found a difference between Granger causality features between exposure to fentanyl versus VX, where fentanyl shows less coherence between respiration parameters than VX, and VX shows less coherence in ECG parameters than fentanyl. Classification analysis shows that the combination of traditional and Granger causality features performs slightly better than traditional features alone. Future research will examine whether, and if so, which, Granger causality features are more robust across variation in species and movement conditions to enhance methods for early and automatic detection of exposure to toxics.
TNO Identifier
1013413
ISBN
978-90-74821-94-0
Publisher
s.n.
Source title
Measuring Behavior 2022, 12th International Conference on Methods and Techniques in Behavioral Research, and 6th Seminar on Behavioral Methods 18–20 May 2022
Editor(s)
Spink, A.
Barski, J.
Brouwer, A.M.
Riedel, G.
Sil, A.
Barski, J.
Brouwer, A.M.
Riedel, G.
Sil, A.
Place of publication
S.L.
Pages
72-82
Files
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