Evidence for synteny between the human loci for the HLA histocompatibility antigen, phosphoglucomutase3, malic enzyme (cytoplasmic), and indophenol oxidase B (tetrameric)
article
In 274 man/Chinese hamster somatic cell hybrids from 20 independent fusion experiments, the segregation of the loci for 27 human enzyme markers and for the species specific surface antigens, including the HLA histocompatibility antigens, was studied. The results show a synteny between the human loci for phosphoglucomutase3, cytoplasmic malic enzyme (ME-1, also known as malate oxidoreductase decarboxylating), indophenol oxidase B (tetrameric), and HLA. Furthermore, the data suggest that the loci for the human species specific antigens are distributed over several chromosomes. Hybrid clones which retained only the genetic information for hexosaminidase B (Hex B) did not react with the tested antisera. But whenever X-markers were also retained in addition to Hex-B, they did give a positive reaction.
Chemicals/CAS: phosphoglucomutase, 9001-81-4; cytochrome c oxidase, 72841-18-0, 9001-16-5; malate dehydrogenase, 9001-64-3; Cytochrome-c Oxidase, EC 1.9.3.1; Histocompatibility Antigens; Malate Dehydrogenase, EC 1.1.1.37; Phosphoglucomutase, EC 5.4.2.2
Chemicals/CAS: phosphoglucomutase, 9001-81-4; cytochrome c oxidase, 72841-18-0, 9001-16-5; malate dehydrogenase, 9001-64-3; Cytochrome-c Oxidase, EC 1.9.3.1; Histocompatibility Antigens; Malate Dehydrogenase, EC 1.1.1.37; Phosphoglucomutase, EC 5.4.2.2
Topics
EnzymePhosphoglucomutaseTransplantation antigenCytochrome c oxidaseHistocompatibility antigenMalate dehydrogenase2 (4 amidinophenyl) 6 indolecarboxamidineCytoplasmGene locusHLA systemIn vitro studyMethodologyNormal humanNormal valueTheoretical studyAnimalCell cloneChromosome mapEnzymologyHamsterHumanHybrid cellAnimalChromosome MappingClone CellsCytochrome-c OxidaseCytoplasmHamstersHistocompatibility AntigensHumanHybrid CellsMalate DehydrogenasePhosphoglucomutase
TNO Identifier
227742
ISSN
03010171
Source
Cytogenetics and Cell Genetics, 13(1-2), pp. 185-186.
Pages
185-186
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