Radioprotection of biologically active DNA by cysteamine: A rapid mix study
article
Protection of purified biologically active bacteriophage DNA by cysteamine against radiation damage was studied in rapid mixing experiments, under conditions where protection is only due to reactions between irradiated DNA and unirradiated protector. It is shown that the formation of single strand breaks, a few msec after irradiation in the absence of oxygen, can be influenced by the addition of cysteamine, leading to a reduction of the number of breaks. The amount of lethal nucleotide damage was shown not to be affected.
Chemicals/CAS: cobalt 60, 10198-40-0; DNA, 9007-49-2; mercaptamine, 156-57-0, 60-23-1; Cysteamine, 60-23-1; DNA, Viral; Radiation-Protective Agents
Chemicals/CAS: cobalt 60, 10198-40-0; DNA, 9007-49-2; mercaptamine, 156-57-0, 60-23-1; Cysteamine, 60-23-1; DNA, Viral; Radiation-Protective Agents
Topics
Cobalt 60DNAMercaptamineNucleic acidProtective agentRadioisotopeBacteriophageCytologyDNA degradationIn vitro studyMethodologyMicroorganismPseudomonasRadiationRadiation injuryRadiation protectionTheoretical studyBacteriophagesColiphagesCysteamineDNA VirusesDNA, ViralDose-Response Relationship, RadiationPseudomonasRadiation EffectsRadiation-Protective Agents
TNO Identifier
227679
ISSN
09553002
Source
International Journal of Radiation Biology, 25(5), pp. 455-464.
Pages
455-464
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