The effect of atropine and methylatropine on the sweat secretion of unrestrained mice, measured with radioactive saline

article

Eick, A.J. van

Bock, J.
Effect of drugs on the natural sweat secretion from the feet of freely moving mice was determined. Mice injected with labelled saline were allowed to move freely on filterpaper. The amount of radioactivity found in the paper is a measure of the sweat produced. The filterpaper was impregnated with bromphenol blue in order to detect contamination by excreta other than sweat. A quaternary derivative of atropine was found to diminish the excretion of radioactive material more than its tertiary analogue.
Chemicals/CAS: atropine methyl nitrate, 52-88-0; atropine, 51-55-8, 55-48-1; methylatropine, 31610-87-4; sodium chloride, 7647-14-5; Atropine, 51-55-8; Radioisotopes; Sodium Isotopes
Topics























AtropineAtropine methyl nitrateMethylatropineRadioisotopeSodium chlorideDose responseDrug excretionDrug responseMousePharmacokineticsSodium chloride na 24SweatSweatingTheoretical studyAnimalAtropineFemaleFootMethylationMiceMice, Inbred CBARadioisotopesSodium IsotopesSweating
TNO Identifier
227669
Repository link
https://resolver.tno.nl/uuid:6a3d4690-3c24-456a-80d5-52bee9f89fc1
ISSN
00142999
Source
European Journal of Pharmacology, 27(2), pp. 263-265.
Pages
263-265
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