Effect of distamycin A on the immune response in vitro against sheep red blood cells
article
The effect of distamycin A (DMC) on the immune response in vitro was studied. The addition of DMC to dissociated mouse spleen cells, obtained from unprimed animals and cultured in the presence of sheep red blood cells as an antigen caused a marked inhibition of the plaque forming cell response when the drug was added during the first 24 hr of culture, but not when it was added later. The response of spleen cells taken from primed mice was more resistant to the immunosuppressive effect of DMC than was the response of unprimed cells. When the effects of DMC were compared to those of the cytosine arabinoside and actinomycin D it was found that neither of the latter two compounds could reproduce the effects of DMC.
Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; distamycin A, 13696-04-3, 39389-47-4, 636-47-5; Amidines; Antibiotics; Cytarabine, 147-94-4; Dactinomycin, 50-76-0; Oligopeptides; Pyrroles
Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; distamycin A, 13696-04-3, 39389-47-4, 636-47-5; Amidines; Antibiotics; Cytarabine, 147-94-4; Dactinomycin, 50-76-0; Oligopeptides; Pyrroles
Topics
CytarabineDactinomycindistamycin aErythrocyte antibodyAntibody productionDrug metabolismErythrocyteImmune responseImmunosuppressive treatmentIn vitro studyPlaque forming cellSheepSpleen cellTheoretical studyAmidinesAnimalAntibioticsAntibody FormationCells, CulturedCytarabineDactinomycinDose-Response Relationship, DrugErythrocytesFemaleHemolytic Plaque TechniqueImmunosuppressionLymphocytesMiceOligopeptidesPyrrolesSheepSpleenStreptomyces
TNO Identifier
227649
ISSN
00221767
Source
Journal of Immunology, 113(1), pp. 424-427.
Pages
424-427
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