Influence of genetic resistance and silica particles on survival after bone marrow transplantation
article
Supralethal total body irradiation (TBI) does not completely suppress resistance to the establishment of a foreign bone marrow (BM) graft. With increasing differences between BM donor and recipient, increasing numbers of BM cell are needed to secure primary survival of the irradiated individual. The term genetic resistance (R) was introduced as a general description of this phenomenon. When donor and recipient differ for the major histocompatibility complex (MHC), R was generally found to be more pronounced than when this is not the case. It is still unknown whether R occurs in man, since the application of human BM grafts has been mainly limited to the use of MHC identical donor recipient pairs, in which R in other species is only weakly present. R has mainly been studied by techniques in which early repopulation events after BM grafts were measured in the spleen by a colony formation assay or the uptake of radioactive 5 iodo 2'deoxyuridine. Studies in which the survival of the irradiated and BM grafted animals was measured are conspicuously lacking. Such studies will reveal the relevance of genetic R to clinical transplantation. R and its abrogation in vivo therefore need to be further defined in animals before guidelines for the treatment of human patients with BM from a donor mismatched at the MHC can be drafted. Such studies were perfomed in mice and dogs, where spleen colony forming units (CFU S), survival of recipients, the genetic control of R and its abrogation by silica particles were investigated. Striking dissimilarities among CFU S assays, silica effects, and survival were noted, which underline the need for survival studies in wellchosen animal models.
Chemicals/CAS: silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Silicon Dioxide, 7631-86-9
Chemicals/CAS: silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Silicon Dioxide, 7631-86-9
Topics
silicon dioxidegraft survivalh2 systemHLA systemimmunogeneticsmajor histocompatibility complexmousetheoretical studywhole body radiationAnimalBone Marrow CellsBone Marrow TransplantationDogsDose-Response Relationship, ImmunologicFemaleGraft vs Host ReactionHaplorhiniHematopoiesisMaleMiceParticle SizeRadiation ChimeraSilicon DioxideSupport, U.S. Gov't, P.H.S.Transplantation, Homologous
TNO Identifier
228111
ISSN
00411345
Source
Transplantation Proceedings, 8(3), pp. 483-489.
Pages
483-489
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