Immunoglobulin patterns in humans over 95 years of age

article




Radl, J.

Sepers, J.M.

Skvaril, F.

Morell, A.

Hijmans, W.
Immunoglobulin patterns were investigated in 73 volunteers older than 95 yr. An idiopathic paraproteinemia was found in 19% of the cases. A restriction of heterogeneity and an imbalance in the kappa/λ ratio of the immunoglobulins was seen in a number of other sera. Determinations of immunoglobulin levels in sera of individuals without paraproteinemia showed an increase in IgA and IgG. The quantitations of the IgG subclasses demonstrated that an increase in the IgG1 and IgG3 subclasses is responsible for the elevated level of the IgG. The variation in the immunoglobulin levels increased significantly with age for IgM and for the 3 major IgG subclasses. No abnormalities were found in the urine or in the mixed saliva. These results indicate that selective changes in the extent of the antibody immunoglobulin repertoire characterize the immunoglobulin pattern of ageing man.
Chemicals/CAS: immunoglobulin, 9007-83-4; Immunoglobulin A; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Paraproteins
Topics























immunoglobulinageagedin vitro studynormal humannormal valuetheoretical studyAdultAge FactorsAgedAgingFemaleHumanImmunoglobulin AImmunoglobulin DImmunoglobulin GImmunoglobulin MImmunoglobulinsMaleMiddle AgeParaproteinemiasParaproteinsSalivaSex Factors
TNO Identifier
227867
Repository link
https://resolver.tno.nl/uuid:df6fc831-2df6-474b-9740-e9ed76480999
ISSN
00099104
Source
Clinical and Experimental Immunology, 22(1), pp. 84-90.
Pages
84-90
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