Immunoglobulin levels as related to age in nonhuman primates in captivity. I. Chimpanzees
article
Immunoglobulin levels in the sera of 60 chimpanzees between 1 and 12 yr of age were determined by single radial immunodiffusion, using antisera against class specific determinants of human immunoglobulins showing a reaction of identity between the human and chimpanzee immunoglobulins. Animals older than 1 yr had IgG (gamma G immunoglobulin) levels which did not differ much from the values of the young adults. In contrast, the IgM (gamma M immunoglobulin) levels remained at about 50% of the young adult values until 7 yr of age, afterwards gradually rising up to the adult values. The IgA (gamma A immunoglobulin) levels, reaching nearly 70% of the adult values even after 1 yr of age of the animals, showed a slow gradual increase. Immunoglobulins of all 3 major classes showed wide variations in value for all age groups. Immunoglobulin D showed a more homogeneous distribution and its concentration did not change substantially with age.
Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin M, 9007-85-6; immunoglobulin, 9007-83-4; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins
Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin M, 9007-85-6; immunoglobulin, 9007-83-4; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins
Topics
immunoglobulinimmunoglobulin aimmunoglobulin gimmunoglobulin mageagingantibody productionhumoral immunityimmunoglobulin blood levelin vitro studymethodologymonkeynormal valuetheoretical studyAge FactorsAnimalFemaleImmunodiffusionImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunoglobulinsMalePan troglodytes
TNO Identifier
227644
ISSN
00472565
Source
Journal of Medical Primatology, 3(6), pp. 335-342.
Pages
335-342
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