Homogeneous immunoglobulins in sera of rhesus monkeys after lethal irradiation and bone marrow transplantation

article




Radl, J.

Berg, P. van den

Voormolen, M.

Hendriks, W.D.H.

Schaefer, U.W.
The immunoglobulin pattern in the sera of lethally irradiated and bone marrow transplanted Rhesus monkeys was studied during te reconstitution of their immune system. All of the irradiated monkeys which survived longer than 30 days, and in which reconstitution of their immune system took place, also developed homogeneous immunoglobulins (HI) in their sera. These homogeneous, sometimes multiple, immunoglobulins were transient. However, they persisted frequently in the sera for several mth. In 2 monkeys which were additionally immunized with a complex antigen (normal human serum), clear cut M components appeared in the serum about 10 days later. These HI of IgM class did not precipitate the antigen in immunodiffusion techniques; however, when passing the serum through an immunoadsorbent prepared from normal human serum, only the HI were specifically retained on the column and afterwards isolated by elution.
Chemicals/CAS: immunoglobulin G, 97794-27-9; immunoglobulin, 9007-83-4; immunoglobulin M, 9007-85-6; Blood Proteins; Gamma-Globulins; Immunoglobulin G; Immunoglobulin M; Paraproteins; Immunoglobulins
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immunoglobulinimmunoglobulin gimmunoglobulin Gimmunoglobulin Mparaproteinplasma proteinantibody productionbone marrow transplantationimmunoadsorbentimmunoelectrophoresisimmunoglobulin blood levelin vitro studymethodologymonkeytheoretical studywhole body radiationX rayagar gel electrophoresisallotransplantationanimalarticlebone marrow cellHaplorhinihumanimmunologyisolation and purificationMacacaradiation chimeraimmunityimmunizationradiation exposureradiation responsetimeAnimalBlood ProteinsBone Marrow CellsBone Marrow TransplantationElectrophoresis, Agar GelGamma-GlobulinsHaplorhiniHumanImmunoelectrophoresisImmunoglobulin GImmunoglobulin MMacacaMacaca mulattaParaproteinsRadiation ChimeraTransplantation, HomologousImmunityImmunizationImmunoglobulinsRadiation EffectsTime Factors
TNO Identifier
227603
Repository link
https://resolver.tno.nl/uuid:0f14d85b-d768-4eca-9701-9fdf24e522e8
ISSN
00099104
Source
Clinical and Experimental Immunology, 16(2), pp. 259-266.
Pages
259-266
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