Evidence for linkage between human loci for 6-phosphogluconate dehydrogenase and phososphoglucomutase<sub>1</sub> in man-Chinese hamster somatic cell hybrids
article
The existence of zymographically detectable interspecific enzyme variations and the preferential loss of human chromosomes in the man-mouse as well as the man-Chinese hamster somatic cell hybrids have rendered these hybrids useful for genetic analysis of man1,2. Of these two systems, linkage studies involving the human locus for 6-phosphogluconate dehydrogenase, 6PGD, have been found feasible only in the man-Chinese hamster hybrids because the usual phenotype of human 6PGD is electrophoretically distinguishable only in this hybrid system3. This report deals with the genetic linkage relations of the human 6PGD locus in man-Chinese hamster somatic cell hybrids and provides the first evidence that the human genes for 6PGD and phosphoglucomutase 1 (PGM1 are syntenic (located on the same chromosome)4. © 1972 Nature Publishing Group.
Chemicals/CAS: glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; glycosyltransferase, 9033-07-2; isocitrate dehydrogenase, 9001-58-5; lactate dehydrogenase, 9001-60-9; malate dehydrogenase, 9001-64-3; oxidoreductase, 9035-73-8, 9035-82-9, 9037-80-3, 9055-15-6; phosphoglucomutase, 9001-81-4; phosphogluconate dehydrogenase, 9001-82-5; phosphoglycerate kinase, 9001-83-6; Glucosephosphate Dehydrogenase, EC 1.1.1.49; Indoles; Isocitrate Dehydrogenase, EC 1.1.1.41; Lactate Dehydrogenase, EC 1.1.1.27; Malate Dehydrogenase, EC 1.1.1.37; Oxidoreductases, EC 1.; Pentosyltransferases, EC 2.4.2.; Phosphoglucomutase, EC 5.4.2.2; Phosphogluconate Dehydrogenase, EC 1.1.1.43; Phosphoglycerate Kinase, EC 2.7.2.3
Chemicals/CAS: glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; glycosyltransferase, 9033-07-2; isocitrate dehydrogenase, 9001-58-5; lactate dehydrogenase, 9001-60-9; malate dehydrogenase, 9001-64-3; oxidoreductase, 9035-73-8, 9035-82-9, 9037-80-3, 9055-15-6; phosphoglucomutase, 9001-81-4; phosphogluconate dehydrogenase, 9001-82-5; phosphoglycerate kinase, 9001-83-6; Glucosephosphate Dehydrogenase, EC 1.1.1.49; Indoles; Isocitrate Dehydrogenase, EC 1.1.1.41; Lactate Dehydrogenase, EC 1.1.1.27; Malate Dehydrogenase, EC 1.1.1.37; Oxidoreductases, EC 1.; Pentosyltransferases, EC 2.4.2.; Phosphoglucomutase, EC 5.4.2.2; Phosphogluconate Dehydrogenase, EC 1.1.1.43; Phosphoglycerate Kinase, EC 2.7.2.3
Topics
Glucose 6 phosphate dehydrogenaseGlycosyltransferaseIndole derivativeIsocitrate dehydrogenaseLactate dehydrogenaseMalate dehydrogenaseOxidoreductasePhosphoglucomutasePhosphogluconate dehydrogenasePhosphoglycerate kinaseBiosynthesisElectrophoresisEnzymologyFibroblastGenetic linkageGeneticsHamsterHumanHybrid cellPhenotypeStructural geneAnimalElectrophoresisFibroblastsGenes, StructuralGeneticsGlucosephosphate DehydrogenaseHamstersHumanHybrid CellsIndolesIsocitrate DehydrogenaseLactate DehydrogenaseLinkage (Genetics)Malate DehydrogenaseOxidoreductasesPentosyltransferasesPhenotypePhosphoglucomutasePhosphogluconate DehydrogenasePhosphoglycerate Kinase
TNO Identifier
280790
ISSN
00280836
Source
Nature, 236(5340), pp. 30-32.
Pages
30-32
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