Are D and DR antigens identical? A review of available data for man and the rhesus monkey
conference paper
In conclusion, my role as devil's advocate against the postulate that D and DR antigens are identical (or controlled by the same gene) has not been very rewarding. On carefully reading the literature, I found that the bulk of the human data indeed support the notion of D/DR identity, and our own monkey data equally advanced as those of man, lead to more or less the same conclusion. However, a few controversial data were found and raised some doubt about D/DR identity. For man, there are several cases of unusual associations between D and DR antigens: especially the DR2 story of Suciu-Foca et al. could lead to a crack in the doctrine of identity. For the rhesus monkey, we have also presented some unexpected data that do not fully support the concept of D/DR identity, but the evidence against identity is still rather thin. Obviously, information on the real nature of D and DR antigens and their relationship will have to come from a biochemical analysis. Here, too, the MLC-stimulating D antigens may, after all, not be identical with the serologically defined DR antigens.
Chemicals/CAS: Antigens, Surface; HLA Antigens
Chemicals/CAS: Antigens, Surface; HLA Antigens
Topics
TNO Identifier
228605
ISSN
00411345
Source
Transplantation Proceedings, 11(1), pp. 657-664.
Pages
657-664
Files
To receive the publication files, please send an e-mail request to TNO Repository.