Influence of a single blood transfusion on kidney allograft survival in unrelated rhesus monkeys
article
A prospective study was performed in moderately immunosuppressed unrelated rhesus monkeys to investigate the influence of a single transfusion on kidney allograft survival. The recipients received either whole citrated blood or plasma-free transfusates consisting of pure red blood cell or lymphocyte suspensions. Except for 1 group, in which blood and kidney donors were optimally matched, transfusions and kidney allografts were disparate for 2 to 4 A/B locus antigens with the recipients. Transfusions were given 2 to 4 wk before kidney grafting, except in 1 experimental group where the recipients were transfused 0 to 12 hr before transplantation. The general trend was that graft prolongation could be obtained with all experimental protocols. However, it was also shown that a single transfusion entails the risk of accelerated rejection. This adverse effect was not observed in the animals receiving blood and kidneys from donors optimally matched for A/B locus antigens and in recipients transfused shortly before or during transplantation. These results may contribute to a further improvement of the current clinical transfusion policy.
Topics
TNO Identifier
228473
ISSN
00411337
Source
Transplantation, 26(5), pp. 325-330.
Pages
325-330
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