Prolongation of heterotopic heart allograft survival in rats by use of antigen antibody complexes

article



Marquet, R.L.

Heystek, G.A.

Tank, B.

Es, A.A. van
Treatment of BN recipients with soluble WAG/Rij histocompatibility antigens (HCA) did not produce prolongation of (WAG/Rij x BN)F1 heart allografts but resulted in specific sensitization of the recipients in most cases. Three different anti WAG/Rij sera (ADS) were tested, either alone or complexed in equivalence to 0.5 mg of HCA. Depending on the serum used, ADS alone produced only a moderate prolongation of heart survival or had no effect at all. Antigen antibody complexes given i.v. on days 0, 2, 4, 6, and 8 induced a prolonged or indefinite cardiac graft survival ( > 200 days), as well as accelerated graft rejection, depending on the source of the ADS used in immune complex formation. One month after heart transplantation, BN recipients, treated with antigen antibody complexes, demonstrated normal graft versus host reactivity of peripheral blood lymphocytes, but rejected donor type skin grafts in a slightly delayed fashion.
Chemicals/CAS: Antigen-Antibody Complex; Histocompatibility Antigens; Immune Sera
Topics




























transplantation antigenantiserumhistocompatibility antigenantigen antibody complexgraft survivalgraft versus host reactionheart transplantationimmunostimulationskin grafttheoretical studyallotransplantationanimalgraft rejectionintravenous drug administrationrat straintimeAnimalAntigen-Antibody ComplexGraft RejectionHeart TransplantationHistocompatibility AntigensImmune SeraImmunityInjections, IntravenousMaleRatsRats, Inbred BNTime FactorsTransplantation, Homologous
TNO Identifier
228123
Repository link
https://resolver.tno.nl/uuid:888575f7-7d36-4158-9d20-a4a6a43ec0ec
ISSN
00411337
Source
Transplantation, 21(6), pp. 454-459.
Pages
454-459
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