Investigation of the rapid recovery of rat thermoregulation from soman poisoning
article
The hypothalamic thermostat of the rat recovers from the hypothermic response brought about by an intracerebroventricular (i.c.v.) injection of soman in little more than 4 hr. It was investigated whether this rapid recovery might be due to a decreased sensitivity of the cholinergic synapses involved, by comparing the responses of the set point for heat release to i.c.v. carbachol before and after soman treatment. It was found that a changed sensitivity cannot explain the recovery since the test responses after recovery from soman were not lower than the pre soman control responses.
Chemicals/CAS: carbachol, 462-58-8, 51-83-2; soman, 96-64-0; Carbachol, 51-83-2; Cholinesterase Inhibitors; Organophosphorus Compounds; Soman, 96-64-0
Chemicals/CAS: carbachol, 462-58-8, 51-83-2; soman, 96-64-0; Carbachol, 51-83-2; Cholinesterase Inhibitors; Organophosphorus Compounds; Soman, 96-64-0
Topics
CarbacholCholinesterase inhibitorSomanBrain ventricleCholinergic synapseDrug intoxicationHypothalamusIntoxicationIntracerebroventricular drug administrationRatTheoretical studythermoregulationAnimalBody Temperature RegulationCarbacholCerebral VentriclesCholinesterase InhibitorsDose-Response Relationship, DrugHypothalamusInjectionsMaleOrganophosphorus CompoundsPoisoningRatsSomanTime Factors
TNO Identifier
227494
ISSN
00142999
Source
European Journal of Pharmacology, 24(1), pp. 105-107.
Pages
105-107
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