Germine monoacetate and 3-chloro-2,5,6,-trimethyl-benzoic acid; Therapeutic possibilities against inhibition of neuromuscular transmission by organophosphorus anticholinesterase compounds

article

Wolthuis, O.L.

Postel-Westra, K.B.
The effects of germine monoacetate and 3-chloro-2,5,6,-trimethyl-benzoic acid (Na-U23223) on the respiratory paralysis caused by DFP and paraoxon were studied in anaesthesized, atropinised rats. It appears that especially Na-U23223 is an effective antidote; it may completely prevent respiratory paralysis induced by 2×LD50 DFP or 4 × LD50 paraoxon. © 1971.
Chemicals/CAS: dyflos, 55-91-4; nitrophenol, 25154-55-6; phosphoric acid, 7664-38-2; Alkaloids; Benzoates; Cholinesterase Inhibitors; Isoflurophate, 55-91-4; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Nitrophenols; Phosphoric Acids
Topics

























3-Chloro-2,5,6-trimethyl-benzoic acid Neuromuscular transmissionCholinesterase inhibitorsGermine monoacetateRespiratory paralysisAlkaloidBenzoic acid derivativeCholinesterase inhibitorDyflosNeuromuscular blocking agentNeuromuscular depolarizing agentNitrophenolPhosphoric acidAnimalMaleRatAlkaloidsAnimalBenzoatesCholinesterase InhibitorsIsoflurophateMaleNeuromuscular Depolarizing AgentsNeuromuscular Nondepolarizing AgentsNitrophenolsPhosphoric AcidsRats
TNO Identifier
227244
Repository link
https://resolver.tno.nl/uuid:06ae511d-6475-4812-acf9-4b0965711376
ISSN
00142999
Source
European Journal of Pharmacology, 14(1), pp. 93-97.
Pages
93-97
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