Primate type-c oncoviruses
article
Mesenchymal tumors such as sarcomas and leukemias are caused by type-C oncoviruses in several animal species. Even in subhuman primates such RNA tumor viruses have been shown to be the natural cause of these neoplastic diseases. Therefore, an extensive search has been made for type-C oncoviruses in human mesenchymal tumors, particularly in leukemia. Numerous claims have been made of the detection of viral footprints in human tumor material. However, there is no general concensus about their validity. A few virus isolates from human cells have been reported which are closely related to known primate type-C oncoviruses. This close relationship has caused skepticism among tumor virologists. Epidemiological studies do not support an association between these viruses and the occurrences of mesenchymal tumors in man. Since no definite conclusions can be made about the existence of human type-C oncoviruses, a critical review of the available data is given. 242 references are cited. Chemicals/CAS: protein, 67254-75-5; RNA, 63231-63-0; Antibodies, Viral; Antigens, Viral; DNA, Neoplasm; Gene Products, gag; RNA, Viral; RNA-Directed DNA Polymerase, EC 2.7.7.49; Viral Envelope Proteins; Viral Proteins
Topics
ProteinInfectionAnimalAntibodies, ViralAntigens, ViralBase SequenceDNA, NeoplasmGene Products, gagGenes, ViralLeukemiaNeoplasmsOncogenic VirusesPapioPhylogenyPrimatesRetroviridaeRNA, ViralRNA-Directed DNA PolymeraseSarcoma Virus, Woolly MonkeyTumor Virus InfectionsViral Envelope ProteinsViral ProteinsVirus Replication
TNO Identifier
228937
ISSN
00063002
Source
Biochimica et Biophysica Acta, 605(4), pp. 461-487.
Pages
461-487
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