Distribution of histamine threshold values in a random population
article
In a random Dutch population, about 17% of the men and women aged 18 to 61 had a histamine threshold value of 16 mg/ml or less. The results of the study in this random population confirm the conclusions from previous epidemiological studies in stratified random samples. All the investigations have shown that there is an association between the presence of a histamine threshold value of 16 mg/ml or less and the presence of respiratory symptoms. The authors also found a correlation between the threshold value and the initial value of the FEV1/IVC (%). Furthermore, there is a relationship with age. No association has been found with exogenous factors like smoking and living in a polluted area, neither with cutaneous allergy and blood eosinophilia, nor with sex. At present it is very difficult to state the significance of finding a positive histamine threshold test. The findings suggest that somewhere in the multiplicity of factors that play a role in the pathogenesis of chronic non specific lung disease, the reactivity of the airways, as indicated by the histamine threshold value, has a place and that most probably this place is closer to the endogenous than to the exogenous side. Chemicals/CAS: histamine, 51-45-6, 56-92-8, 93443-21-1; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2
Topics
TNO Identifier
227536
Source
Revue de l'Institut d'hygiene des Mines, 28(4), pp. 186-190.
Pages
186-190
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