Determination of concentration-time-mortality relationships versus LC50s according to OECD guideline 403
article
The effect of decreasing the number of animals on the accuracy of estimated concentration-time-mortality relationships and the LC50 values derived from these was investigated by means of simulation methods. Studies of NH3, Cl2, H2S, and COCl2 were made using 5 rats per sex per group. Mortality rates were analysed in 500 new data sets obtained by randomly removing 4 rats/sex/group from the original data sets. It was concluded that the concentration-time-mortality relationship and the LC50 values can be determined over a 5-10-fold time range using one rat/sex/group. The resulting 5 and 95 percentiles compare favourably with the 90% confidence limits when determining a LC50 according to OECD guideline 403. When using concentration-time-mortality relationships, additional information can be obtained which can be used in inhalation hazard risk assessment.
Topics
concentration-time-mortalityguideline 403, OECDinhalation toxicityLC50 valueOECD guideline 403toxicity, inhalationanimal cellconcentrationconference papermortalitynonhumanpriority journalrattimeAdministration, InhalationAmmoniaAnimalChloridesDose-Response Relationship, DrugFemaleHealth PlanningHealth Planning GuidelinesHydrogen SulfideLung DiseasesMaleMortalityRatsRats, Inbred StrainsRisk FactorsStatisticsTime Factors
TNO Identifier
230975
ISSN
02321513
Source
Experimental Pathology, 37(1-4), pp. 62-66.
Pages
62-66
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