Genotoxic effects of intragastrically administered benzo[a]pyrene in rat liver and intestinal cells

article




Mullaart, E.

Buytenhek, M.

Brouwer, A.

Lohman, P.H.M.

Vijg, J.
The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.
Chemicals/CAS: benzo[a]pyrene, 50-32-8; Benzo(a)pyrene, 50-32-8; DNA, 9007-49-2
Topics

















benzo[a]pyreneanimal cellanimal experimentgenotoxicityintestine cellliver cellnonhumanoral drug administrationratAnimalBenzo(a)pyreneDNAFemaleIntestinesLiverRatsRats, Inbred BNStomach
TNO Identifier
230867
Repository link
https://resolver.tno.nl/uuid:d7e3f5e7-2844-4097-9e9e-2d2de5067b01
ISSN
01433334
Source
Carcinogenesis, 10(2), pp. 393-395.
Pages
393-395
Files
To receive the publication files, please send an e-mail request to TNO Repository.